BCDI - Atlanta LEAN

Understanding Glioblastoma: The Most Aggressive Brain Cancer

Glioblastoma, also known as glioblastoma multiforme (GBM), is the most common and aggressive type of malignant brain tumor in adults. Despite advances in neuroscience and oncology, glioblastoma remains one of the most challenging cancers to treat due to its rapid growth, complexity, and resistance to conventional therapies. Affecting thousands of people each year worldwide, GBM requires a multidisciplinary approach involving neurosurgery, radiation, and targeted drug therapy to improve patient outcomes.

What Is Glioblastoma?

Glioblastoma arises from astrocytes, star-shaped cells in the brain that support and protect neurons. These tumors are classified as grade IV astrocytomas, meaning they are highly malignant and grow rapidly. Unlike many other cancers, glioblastoma does not typically spread to other parts of the body but infiltrates nearby brain tissue, making complete surgical removal nearly impossible.

GBM can develop de novo (primary glioblastoma), which is the most common form and…